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Cell Activation
Cell Activation is an easy and simple methodology for lifestyle optimization suited for the modern lifestyle aiming at stimulating each cell of the human body to function in the optimal way. Hippocrates observed, ‘If we could give every individual the right amount of nourishment and exercise, not too little and not too much, we would have found the safest way to health.’ The search for the safest method to ensure every individual receives the right amount of nourishment and exercise, not too little and not too much lead to the development of Cell Activation. It has three aspects. 1. Cell nutrition. 2. Cell stimulation. 3. Cell support.
Cell Nutrition
Scientific research and development in the field of nutrition, health, disease and treatment has identified and quantified requirement for each of the nutrients for humans at different stages of life. The modern high calorie, high omega 6 fat, high sodium, low fibre, low omega 3 fat, low potassium diet along with lack of supportive physical activity is the major causative factor of the DRNCD (diet related non communicable diseases) / lifestyle diseases. A very dangerous trend is the presence of so called fillers which form the bulk of many processed food products which negatively affect the health of the consumers whether a child or an adult. Another important factor is the increasing level of toxins in the form of pesticides, weed killers, preservatives, colouring and flavouring agents in the modern day food.
An ideal food should contain all nutrients in the correct proportion and be devoid of any toxic content. There is no natural food in the world which meets all nutritional requirements of the human except breast milk up to the age of 6 months, provided mother gets adequate nutrition. Hippocrates said “Let food be your medicine and medicine be your food.” The search for this ideal food with nutrients in correct proportion without added fillers,colour, preservatives, flavours and minimizing the risk of pesticide and weed killer residues lead to the development of optimised nutrient foods.
Cell Stimulation
Mechanisation in all aspects of modern life has reduced physical activity and calorie requirement in day to day life. Excess calories in the diet will be stored as fat. The easy availability of high calorie processed food rich in sugar, starch and unhealthy fats leads to overweight and obesity. This overweight and obesity is the stepping stone towards an array of lifestyle diseases. Actually overweight and obesity are forms of malnutrition (improper nutrition).This malaise is no longer a disease of the developed world or rich society, it is drastically increasing among the poor in the developing world also.
Hippocrates noticed ‘That which is used - develops, that which is not used wastes away’. Regular stimulation of cells in the body is needed to keep the cells healthy in this sedentary lifestyle. An ideal stimulation protocol should result in stimulation of all the cells in the body without negatively stressing any part of the body.
There are around 600 muscles in our body. There is an emerging understanding of how skeletal muscles release myokines when they are activated. Muscles produce myokines which act as mediators of physical and mental fitness. Different muscle fibre types -slow twitch muscle fibres, oxidative muscle fibres, intermediate twitch muscle fibres, and fast twitch muscle fibres - release different clusters of myokines during contraction. Myostatin, LIF, IL-6 and IL-7 are involved in muscle hypertrophy and myogenesis, whereas BDNF and IL-6 are involved in AMPK-mediated fat oxidation.
S IL-6 has systemic effects on the liver, adipose tissue and the immune system, and mediates crosstalk between intestinal L cells and pancreatic islets. Other myokines include osteogenic factors IGF-1 and FGF-2; FSTL-1, which improves endothelial function of the vascular system. Studies in the past few years suggest the existence of yet unidentified factors, secreted from muscle cells, which may influence cancer cell growth and pancreas function. Many proteins produced by skeletal muscle are dependent upon contraction; therefore, physical inactivity leads to an altered myokines response, which could provide a potential mechanism for the association between sedentary behaviour and many chronic diseases.
Most exercises we adopt currently like walking, swimming, cycling, and aerobics are usually stimulating only some parts excessively. This can lead to wear and tear of some parts of the body and some other parts may not be used at all. For example during walking buttocks and some muscles of lower limb get activated repeatedly. This excess use of some part alone can lead to long term problems like damaging the joints, especially knee joints. The damage can be more in obese due to the excess weight on the weight bearing joints. The vertebral and abdominal muscles will not get much exercise by walking. This lack of balanced activity is the major reason for growing abdominal obesity, back pain, neck problems and disk prolapse. Many become victims of lifelong painkilling drugs, balms or undergo surgeries which at best give temporary relief without removing the underlying cause.
The search for developing an easily adaptable pattern which follows the principles of total, moderate, practical (even for the lifestyle disorder patient) and stress reversing activity lead to the development of cell stimulation protocol, named oxyflex. It is a series of breath controlled, segmental movements for improving circulation, oxygenation and removal of metabolic waste from the cells. This involves segmental stimulation of all the cells of the body by gentle movement, massage, vibration and thought process. All parts of the body including internal organs and internal muscles are stimulated in a systematic, proportionate way as per the individual requirements. No part is stimulated to excess or too little in cell stimulation protocol.
It is done in lying / sitting position on a comfortable soft mattress preferably on the bed. No special space or equipment is needed. After initial training no supervision is needed for regular practice. As it is done in lying/ sitting position it will not strain the leg/ knee and is suited for overweight/ obese, postoperative/ recuperating patients as it is individualized as per need.
Cell Support
Cell support includes cell protection and stress utilisation. Cell protection is made possible by reducing the avoidable functional burden on the cells physically and chemically. Our body is covered and protected from environmental factors externally by skin and internally by mucous membrane. Inside this physical barrier immune system has an array of defence mechanisms for protection from environmental factors. The range of lifestyle diseases has grown rapidly in recent years. Exposure to environmental pollution, chemical load, (products applied on the face, skin, hair and other daily use products ), increased radiation and the modern sedentary lifestyle easily break down the already weakened immune system.
Chronic stress (Negative stress) makes changes in neuroendocrine function leading to psychological disorders and immune system dysfunction. Optimal cell nutrition and cell stimulation improves the body's ability to withstand stress. Stress relief can prevent stress related psychological disorders like depression, irritability and physical disorders like overeating and obesity which are the stepping stones towards an array of lifestyle diseases. Stress related neuroendocrine changes can lead to immune system dysfunction leading to lifestyle disorders like diabetes, hypertension, cancer etc. Stress relief has a major role in preventing lifestyle disorders. Specific stress utilisation, relief and relaxation methods are included in this Cell Support protocol.
Increase of human population, industrialization, fossil energy use and modern lifestyle has resulted in toxic load in the air we breathe and the water we drink. Atmospheric radiation hazard increases with ozone layer damage, atomic energy use and rampant wireless technology. Food additives for preservation, texture, colour and taste enhancement with low fibre put strain on intestinal microbes, digestive system and associated immune system. Perfumes, deodorants and smoke can damage the lung mucosa and associated immune cells. Cosmetics, hair and nail colour, body care products and cleansing agents all put the skin and associated immune system on added strain.
Many harmful chemicals get into our body without giving warning signs especially those in combinations masking taste and smell as food additives and ingredients and as cosmetics and body care products. Their long term use will harm the body especially the immune system leading to immune dysfunction like cancers, autoimmune diseases and excretory system damage leading to organ failure like kidney failure, liver failure and so on. We get sick when our immune system cannot handle the challenges successfully. This can take different forms like infections, allergies, cancer, inflammatory diseases like heart attack or autoimmune diseases like arthritis.
Support for cells is planned by identifying the personal risk factors after analysing the lifestyle to find the possible preventive measures. Lifestyle burden impact is highest on the skin cells. An ideal skin care product should contain only nutrients which nourish the skin and protects the cells from environmental factors. The search for such a skin care product lead to the development of optimized nutrient skin care, the nutrition oriented body care preparations. Along with optimized nutrient compositions, few simple lifestyle modulations can slow down aging process, inflammation, development of cancer and autoimmune diseases.
Optimized Nutrient Food
Search for an ideal diet with all nutrients in optimal proportion suited for the modern lifestyle lead to the development of optimized nutrient food. Patent application was submitted in India in 2014 September and to WIPO (World Intellectual Property Office) in 2015 and published in 2016 as WO2016035095 A1. After receiving the international search report and preliminary examination report on patentability national entry applications were submitted in 121 countries in 2017 covering all the major countries around the globe. As per the optimized nutrient food formula, combinations varying from 450 kcal to 4000 kcal or more can be made containing all nutrients in ideal proportion as per requirement. This is an essential nutrient rich low calorie food and can be added with carbohydrate and fat with omega 3, 6 ratio 1:1 for increasing calories as per activity level of each person. Methods of preparation of the optimized nutrient food are developed in such a manner only added ingredients which serve a nutrient purpose and no preservatives, colours or flavouring agents. Food products used in the Cell Activation Program(CAP) have no added colour, flavour, preservatives or other additives of no nutritional value.
Optimized Nutrient Fatty Acid Composition
Scientific studies show a clear relationship between diet, genetics and health. Many studies suggest that human beings evolved on a diet with a ratio of omega 3 to omega 6 essential fatty acids (EFA) of approximately 1:1. In the modern diet, the ratio has changed drastically. Modern diets are deficient in omega-3 fatty acids, and have excessive amounts of omega-6 fatty acids compared with the diet on which humans evolved and their genetic patterns were established.
It is needed to know the importance of a crucial component in our body composition for this. The opposing effects of omega-3 and omega-6 fatty acids on human health are due to three molecular mechanisms: 1) they compete for the same set of enzymes to produce signalling molecules that have opposing physiological functions. While omega-3 derived signalling molecules are anti-inflammatory, omega-6 derived are pro inflammatory; 2) they compete for direct transcription factors binding to modulate the expression of different sets of target genes; and 3) they compete to incorporate into cell membranes, directly impacting the function of the cell.
Omega-3 and omega-6 fatty acids compete for the same enzymes to produce eicosanoids and DHA-derived decosanoids with opposing physiological functions. Many omega-3 and omega-6 fatty acids derived eicosanoids and docosanoids directly bind to nuclear hormone receptor transcription factors to modulate the target gene regulation. Omega-3 and omega-6 fatty acids also compete to incorporate into cell membranes, directly impacting the function of the cell. The opposing effects of omega-3 and omega-6 fatty acids lead to the omega-6 to omega-3 ratio so crucial in human growth, health and development. In those who are genetically predisposed to certain cancers, diabetes, heart disease etc the importance of omega 3 and 6 ratio is greater considering its effect on transcription factors and keeping the omega 6 to omega 3 ratio low in their diet will delay or even prevent the occurrence.
Most of the cooking oils, fats in different forms currently available are having a high content of omega 6 fat and almost no omega 3 fat. Most of the nuts/ oil seeds like cashews, peanuts, badam, pista, sunflower seed, cotton seed etc. have a high omega 6 fat content and no omega 3 fat. Small amount of omega 3 linolenic acid in the cereals and pulses are usually lost during processing and in effect omega 6 content is very high and omega 3 content is almost nil or very low. When the omega 6 linoleic is in high concentration even the available little amount of omega 3 linolenic acid will not be converted to active derivatives of omega 3 due to competition for the enzyme from omega 6 linoleic acid.
It is ideal to have a diet with omega 3 and 6 fats in 1:1 ratio and it is the solution that the body asks for overcoming many health problems. There is no such food/ oil available in nature. Omega 3 fat has 3 or more unsaturated double bonds and omega 6 fat has 2 or more double bonds and are highly unstable and prone to oxidative damage in the shelf and after absorption into the body. The polyunsaturated fatty acid (PUFA)omega 3 and 6 and its metabolites with higher level of unsaturation called long chain polyunsaturated fat(LCPUFA) if taken without sufficient antioxidants to protect its double bonds can lead to oxidative cell damage. The high intake of PUFA without proportionally high quantity of antioxidant is detrimental to health due to possible oxidative damage to cell membranes.
Search for a practical solution to correct omega 3 and 6 fats in cooking /cosmetic oil which can resist oxidative damage in the shelf and inside the body lead to the development of optimized nutrient oil. The patent application was submitted in India in 2014 november and to WIPO (world intellectual property office) in 2015, published in 2016 as WO2016071927 A3 After receiving the international search report and preliminary examination report on patentability national entry application was submitted in 121 countries in 2017 covering all the major countries around the globe.
Optimized Nutrient Salt
Evolutionally as a terrestrial animal, human kidney has the capacity to retain sodium and can live with as low as around 500 mg of sodium per day. But our capacity to retain potassium is low. Many studies show there is a deficiency in potassium intake and an excess intake of sodium in the modern diet. For optimal functioning of body sodium to potassium ratio in the diet and body should be around 1:3, but in modern diet it is showing a tendency for reversal of the ratio leading to lifestyle diseases like hypertension, cardiovascular diseases, stroke, urinary stone and osteoporosis.
To solve the problem of potassium deficiency and sodium excess in the diet and associated lifestyle disease challenges we need a salt composition which has a proportion of sodium and potassium 1:3 ratio. Search for an ideal salt composition resulted in the development of optimized nutrient salt. The patent application was submitted in India in 2017 February and to WIPO (World Intellectual Property Office) in 2018 January.
Centre for Reproductive Care
All these scientific theories and practical implementation protocols were developed by Dr. Jolly Thomson, while she was practicing at Centre for Reproductive Centre Thevara, Kochi. Long years of practice and experience in the field of infertility, pregnancy care and gynaecology had given more insight into the importance of lifestyle factors and the need for lifestyle correction. All the latest advances in ART techniques and medications to prevent implantation failure did not show expected results. The number of couples with failed IVF after multiple attempts was on the rise. Lifestyle correction and weight reduction showed a much greater success rate especially when the nutrition intake was optimized in couples with multiple IVF failures. This showed that many of the interventionist procedures could have been avoided. This was a turning point as a less stressful but very successful solution was possible using this lifestyle correction protocol.
It was very easy to understand that infertility as a problem was increasingly affecting couples because of their lifestyle. Though the couples were of very different backgrounds they seemed to all suffer from these lifestyle problems. It was from very careful observation that the common factors in the foods that were eaten become evident in spite of great variations in income and nature of employment. Similarly the chemical loads that the couples were exposed too were similar as the basic nature of many of the products was the same. Regarding physical activity there seemed to be a lot of variation across different strata. It was negative stress that was again quite prevalent across the range.
This showed infertility had become a major lifestyle disorder. The advantage of infertility patients being able to avoid diagnostic interventions, surgical interventions, heavy medications and the constant stress opened up the possibility of using the same opportunity for other lifestyle diseases. The basic causative factors of such lifestyle disorders lay in the lifestyle itself and failure to understand the needs of the body. This required that the individual is able to take an informed decision on crucial lifestyle matters like food, activity and environmental factors and not get misled by all sorts of misleading or biased information. The next step was to provide a simple program to reverse the years of neglect of the body and begin a new, more confident life. Just as it was a greatly satisfying to utilise such an opportunity when a new life was about to begin, similar was the experience when individuals who entered the program started discovering immediate changes in their daily lives that showed how they were beginning to reverse many of the health issues and discomforts they had accepted as a part of their lives.
The encouraging result of lifestyle correction gave inspiration for developing easier implementation techniques which lead to the development of Cell Nutrition ,Cell Stimulation and Cell Support protocols.Benefits of these protocols are widespread. A pregnant patient was diagnosed with congenital abnormality to foetus at 16 weeks of gestation in ultrasound scan.The patient started on the diet. Repeat scan showed complete reversal of the anomaly. These experiences lead to setting up a centre focussed on the prevention and reversal of lifestyle diseases by lifestyle correction minimising medicine and surgery. Thankfully children are the easiest to benefit from lifestyle correction as the results are easy to follow. However this required active parental support. Regarding youth the focus was on avoiding lifestyle pitfalls and being better equipped to take the opportunities. Adults had the body defences strengthened to overcome health challenges. Senior citizens enjoyed a better quality of life and reversal of ill health,pains and aches giving them a better opportunity to enjoy their time with greater independence. The science behind the protocol was also quite refreshing to many senior citizens who had wished for a more transparent and healthier solution to their health challenges and now had more time to devote for the same.
Patents
Optimized Nutrient Food
Optimized Nutrient Fatty Acid Composition
Optimized Nutrient Salt Composition
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